Abstract
Studies on the effect of methotrexate on the uptake and distribution of tritiated amino acids in young rat epidermis are described. The drug given up to 72 hours before the tritiated precursors had no demonstrable effect on either the quantitative uptake using a new solubilization technique for scintillation counting, or on the qualitative distribution using autoradiography. There was no apparent effect over 24 hours if given shortly after the tritiated amino acids using autoradiography. It is concluded that methotrexate has no gross effects on amino acid incorporation in young rat skin.
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