Abstract
Abstract A single intravenous injection of antigen in adult rabbits was shown to depress specifically antibody synthesis upon subsequent immunization with antigen in complete Freund's adjuvant. The degree of tolerance was dependent upon the dose of antigen and the time interval between intravenous antigen and immunization with antigen in adjuvant. Tolerance could not be transferred passively to normal rabbits with serum from tolerant animals and could not be overcome by using a supraoptimal immunizing dose of antigen in Freund's adjuvant. Partial tolerance resulted in a moderate depression in the average affinity of the antibody synthesized.
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