Abstract
Stage radiosensitivity and DNA synthesis were studied in x-irradiated human kidney cells by means of thymidine-3 H labeling and autoradiography. The frequency of diplochromosomes tends to decrease, whereas the polyploids increase with the time after irradiation. Though aberrations were distributed throughout in the cells that were in both S and G2, the frequency of chromatid aberrations in irradiated cells reached a peak at G2, followed by late S, and early and mid-S stages were the lowest. The data showed an increase in chromatid deletion and chromatid exchange as the cell proceeded to G2, and the frequency of isochromatid deletion was constant from S throughout G2. The rate of DNA synthesis and labeling intensities in irradiated cells was lower than that in the control.
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