Abstract
SUMMARY The accuracy of rinderpest virus titrations in primary calf kidney cultures was determined using different dilution intervals, varying numbers of replicate cultures per dilution and cultures derived from different calves. The major source of variance was the differing sensitivity of successive batches of cells. Confidence limits (99%) were established for the mean of 3 successive titrations of batches of rinderpest cell culture vaccine, using 10 -fold or 2 -fold dilution intervals. The variability in the titre of virus in single ampoules which had been lyophilised in Edwards’ centrifugal freeze-driers was investigated. There was no significant correlation between variations of titre and different freeze-drying machines, or positions within the primary drying chambers of individual machines.
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