Abstract
An attempt has been made to study long-term effects of low concentrations of colchicine on synaptic plasticity at the rat neuromuscular junction. In contrast to earlier studies, only minor electron microscopical changes were seen in intra-axonal contents, but fibrillation and occasional slight spread of acetylcholine sensitivity were seen in the colchicine-treated preparation. Reinnervation, cross innervation, and hyperinnervation proceeded in the normal way. No dual innervation was found. Attachment of an accessory nerve produced weight gain, stronger twitches, and shortening of contraction time. The results suggest that, to interfere with the various neurotrophic functions studied, a disturbance in axoplasmic flow must be precisely timed or that neurotubules must be permanently destroyed.
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