Abstract
Treatment of pyrimidine nucleosides with hydroxylamine-O-esters (or hydroxylamine-O-aryl ethers) produced the corresponding 3-amino derivatives. 3-Aminouridine derivatives underwent deamination and acetylation to give uridines and 3-acetamidouridines, respectively. 3-Aminocytidine derivatives underwent, in addition to deamination, replacement with a sulfhydryl and cyclization with an orthoformate to give 3-amino-4-thiouridine and 1, 2, 4-triazolo [2, 3-c] pyrimid-5 (6H)-one derivatives, respectively. Proton magnetic resonance and ultraviolet data of 3-amino derivatives are tabulated.
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