Abstract
Bredinin, C9H13N3O6, is, a novel imidazole nucleoside with an immunosbppressive activity. It was isolated from the culture filtrate of Eupenicillium brefeldianum M-2166 by means of ion-exchange or partition chromatography. Bredinin shows selective cytotoxicity against L5178Y cells derived from malignant lymphoma of the mouse. As an immunosuppressant, it has favorable characteristics, namely, a potent activity, low acute toxicity, and a slight effect on a decrease of peripheral leukocytes. Bredinin inhibits the growth of vaccinia virus but not that of bacteria or fungi except for Candida albicans in vitro.Slight prolongation in the survival period of mice inoculated with lymphatic leukemia L1210 was observed by intraperitoneal injection of bredinin, however, it was not effective on P388 leukemia or EHRLICH ascites tumor.
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