Abstract
Biotin requirements for the growth of a mutant (KY–21–1–25–43–101) of a biotin-producing bacterium (Bacillus sp. KY–21–1–25) was examined and the characteristics of the biotinvitamers produced by the mutant was also examined. Either biotin or dethiobiotin supported the growth of the mutant, but pimelic acid, 7-keto-8-aminopeIargonic acid and 7, 8-diamino-pelargonic acid did not support the growth of the mutant. Biotin-vitamers produced from pimelic acid by the mutant were identified as 7-keto-8-aminopelargonic acid and 7, 8-diamino-pelargonic acid. Dethiobiotin was not produced from pimelic acid by the mutant. Intact cells of the mutant had no capacity to synthesize dethiobiotin from 7, 8-diaminopelargonic acid, while the parent strain had a high potency for dethiobiotin synthesis from 7, 8-diamino-pelargonic acid. The mutant had high potency for biotin production from dethiobiotin that was the same as that of the parent strain.
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