Abstract
In anesthetized bullfrogs, rabbits and a dog the effect of peptic and tryptic digestion of the hind legs on blood pH, CO2, O2, Cl and N.P.N. was observed. No constant significant change was found and the conclusion is drawn that Calude Bernard’s phenomenon can be explained as slow acid corrosion and subsequent digestion of devitalized tissues. The results confirm the necessity of assuming an additional factor (devitalization) of tissues in the occurrence of gastroduodenal ulcer. Alternation of peptic and trypic digestion greatly increased the rate of digestion.
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