Abstract
Events associated with the replication of two spontaneous temperature-sensitive mutants (ts1 and ts3) of Moloney murine leukemia virus were studied under non-permissive and permissive conditions of infection. From temperature-shift experiments ts1 appears to have a temperature-sensitive step occurring early in the growth cycle and in an unidentified function. The temperature-sensitive defect of ts3 occurs late in the replicative cycle. Electron microscope studies showed that although budding partially occurs at the nonpermissive temperature there is no release of virus particles from the cell membrane. The defect of ts3 was also found to be in one of the factors required for the rescue of MuSV.
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