Abstract
Spectrophotometric measurements of nuclear DNA have been made in 3 cases of clear-cell adenocarcinomas of the vagina and 3 with adenosis. There was a history of maternal ingestion of diethylstilbestrol (DES) in all but one of the patients; one patient with an adenocarcinoma was conceived prior to the use of DES in pregnancy. DNA studies showed each of the adenocardinomas to be aneuploid whereas each of the adenosis specimens was in the diploid-tetraploid range. By analogy with results of DNA studies in other gynecologic malignancies, it is suggested that if adenosis is the tissue in which the clear-cell adenocarcinoma arises, it should have a precursor stote with a shift toward aneuploidy which has not been identified in this study.
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