Abstract
Ornithine decarboxylase activity in rat heart was increased significantly by the injection of l-norepinephrine or nisoxetine, an inhibitor of norepinephrine uptake. The enzyme was also increased after 3 h of forced exercise. Propranolol, a β-noradrenergic blocking agent, prevented the enzyme increase after norepinephrine, nisoxetine and exercise. Chemical denervation with 6-hydroxydopamine prevented the effect of nisoxetine but not the effect of l-norepinephrine or exercise. Neither propranolol nor 6-hydroxydopamine significantly affected enzyme activity by themselves, suggesting that tonic noradrenergic input is not necessary for maintenance of basal ornithine decarboxylase activity in heart. These results extend previous literature indicating that cardiac ornithine decarboxylase can be elevated by increased noradrenergic input acting via β-receptors.
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