Abstract
Sarcoplasmic reticulum (SR) Ca2+-ATPase (SERCA) and phospholamban (PLN) form a 116 kDa membrane protein complex that transports Ca2+ from the cytosol into the SR of cardiomyocytes. Owing to their importance for cardiac muscle function, PLN and SERCA have been targeted in therapeutic studies aimed at relieving heart failure. PLN consists of a transmembrane helix (domain Ib and II, residue 23-52) connected to a cytoplasmic region (domain Ia, residue 1-16) by a short loop (residue 17-22). Domain Ia is in a conformational equilibrium between an unfolded, solvent-accessible R state and a helical, membrane-associated T state.
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