Abstract
The aim of this thesis is to improve our understanding of the structure of charged two-component lipid membranes and to give insights into the mechanisms behind colloid-membrane interactions.The samples investigated were composed of single phospholipid bilayers as well as two-component lipid bilayer systems with varied charge density. X-ray reflectivity was used to investigate detailed structural characteristics of these mixed bilayers. We used scanning transmission X-ray microscopy to image positively charged polystyrene latex microspheres which bind onto supported lipid membranes, composed of charged and neutral lipid species. Preferential binding of microspheres to the oppositely charged bilayer was observed.The aim of the last part was to study how charged membranes response to oppositely charged polyelectrolyte-coated gold nanoparticles. We have used fluorescence microscopy and X-ray reflectivity methods to probe the interactions between polyelectrolyte coated gold nanoparticles and supported lipid membranes as well as giant unilamellar vesicles. The results demonstrate the importance of the pH and ionic strength as a modulating parameter of the interaction.
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