Abstract
A continuing study of <i>Catharanthus lanceus</i> alkaloid fractions, in a search for new antineoplastic alkaloids, has led to the isolation of Catharine, a dimeric indole alkaloid found previously only in the related <i>C. roseus</i>. High resolution mass spectrometric measurements have shown that Catharine has the formula C<sub>46</sub>H<sub>54</sub>N<sub>4</sub>O<sub>10</sub> and is made up of a vindoline moiety and an alkaloid moiety with a molecular formula of C<sub>21</sub>H<sub>23</sub>N<sub>2</sub>O<sub>4</sub>.
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