Abstract
Chemokine receptors, which belong to the G protein-coupled receptor (GPCR) family of proteins, are critical regulators of cell migration in the context of immune surveillance, inflammation, and development. Recently determined structures of chemokine receptor CXCR4 reveal unique structural features, and offer templates for homology modeling of other chemokine receptors, which deepen our understanding in ligand-binding modes and signal transduction mechanisms. Dimerization, another intriguing issue for GPCR research, is also reviewed based on all published GPCR structures.
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