Abstract
Programmed cell death (PCD) maintains the tissue size in a multicellular organism. Uncontrolled PCD in neurons has long been implicated in neurodegenerative diseases, e.g. Alzheimer's disease. p75 neurotrophin receptor (p75NTR) acts as a switch of a neuron's fate in maintaining neuronal growth as well as triggering apoptosis. p75NTR, the founding member of tumor necrosis factor (TNF) receptor superfamily, is a type I transmembrane protein. The membrane complex formation of the pro-NGF, p75NTR and sortilin initiates the apoptotic signaling.
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