Abstract
IT has been known for some time that mature virus particles of the pox group contain a brick-shaped central body, or nucleoid, surrounded by an outer layer of protein1. The fact that in pepsin-treated particles this nucleoid cannot be hydrolysed by deoxyribonuclease alone, but only by deoxyribo-nuclease followed by a further pepsin digestion, has been taken as an indication that the nucleoid itself contains protein as well as nucleic acid2. However, when mature vaccinia virus particles are examined with the electron microscope in thin sections after either osmium or ethanol–acetic acid fixation, the nucleoid presents a more or less homogeneous appearance3.
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