Structural Changes in the Myocardium of Old Rats with Stress-Induced Arterial Hypertension

Abstract

Histological changes in the myocardial structure in old rats are estimated against the background of persistent arterial hypertension in this work. The goal was to study the structural organization of myocardial tissues and vessels in animals on the 3rd, 7th, and 30th days after the development of stress-induced arterial hypertension. The experiments were carried out on 28–30-month white outbred male rats. The pathological condition was modeled according to a patented method in a specialized cage with the combined effect of a number of stimuli (light, sound, electricity). The development of destructive and dystrophic disorders in myocardial tissues and vessels, the progression of interstitial and perivascular edema, and the occurrence of diapedetic hemorrhages were demonstrated. It was established that there are significant differences in the morphological structure of the myocardium in animals with hypertension as compared to animals with normal pressure in the control group. This makes it possible to clarify the pathogenesis of the development of stress-induced arterial hypertension, which is a key element for the development of modern antistress and antihypertensive therapy.