Abstract
The paper gives the data of current studies, which suggest the dual mechanism of action of strontium ranelate on bone remodeling in postmenopausal osteoporosis (OP): the drug made bone rearrangement balance shift toward a predominance of the processes of new bone formation. Long-term studies dealing with the use of strontium ranelate to treat postmenopausal OP have supported its safety and efficacy. Strontium ranelate is stated to be the drug of choice in treating his pathology, the duration of the therapy may be as long as 8 years. Indications for its use may be further extended after clinical trials.
Highlights
The paper gives the data of current studies, which suggest the dual mechanism of action of strontium ranelate on bone remodeling in postmenopausal osteoporosis (OP): the drug made bone rearrangement balance shift toward a predominance of the processes of new bone formation
Long-term studies dealing with the use of strontium ranelate to treat postmenopausal OP have supported its safety and efficacy
Strontium ranelate is stated to be the drug of choice in treating his pathology, the duration of the therapy may be as long as 8 years
Summary
The paper gives the data of current studies, which suggest the dual mechanism of action of strontium ranelate on bone remodeling in postmenopausal osteoporosis (OP): the drug made bone rearrangement balance shift toward a predominance of the processes of new bone formation. В исследованиях SOTI и TROPOS отмечены достоверное повышение уровня костной ЩФ (КЩФ) и карбокси-терминального пропептида проколлагена I типа (PIPC) — маркеров костеобразования, — а также снижение концентрации Стерминального телопептида коллагена I типа (СТХ) — маркера костеразрушения — у пациенток, получавших стронция ранелат, по сравнению с этими показателями в группе плацебо, а также с исходными значениями, что фиксировалось в течение всего периода наблюдения.
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
