Strontium Oxide Functionalized Chitosan as Novel Bioaffinity Layer for Construction of Multipurpose Biosensor Platform

Abstract

The wet chemical technique was used to create a biofriendly composite consisting of Strontium Oxide hybridized chitosan (SrO-CS). A spectroscopic analysis revealed that the CS amine group is mostly hybridized with the SrO nanoparticle. The crystalline phases of the nanoparticle are visible in the as prepared SrO-CS. Morphological studies show that the SrO nanorods are covered in CS flakes. The greater electron transfer rate is demonstrated by the SrO-CS modified GCE, which follows a surface confined mechanism at the interface. The SrO-CS modified screen-printed electrode was used to immobilize miRNA sequences in order to selectively detect exosomal CD24 oligonucleotides that are suitable for a broad spectrum of target analyte detection. For biosensor applications, the created SrO-CS functions as a useful bio-affinity layer for biomolecule attachment.