Abstract
The addition of strontium chloride to suspensions of washed human platelets induced biosynthesis of thromboxane B 2 (TxB 2) and secretion of [ 14C]-5-hydroxytryptamine (5HT) in a dose dependent manner. Both responses occurred maximally within four minutes and were inhibited competitively by the presence of calcium ions. Magnesium and lanthanum ions also inhibited both the production of thromboxane B 2 and secretion of 5HT in response to strontium ions. Inhibition of platelet thromboxane generation by aspirin resulted in an almost total inhibition of the secretion response after adding strontium ions. In addition, both the secretion of 5HT and thromboxane B 2 production in the presence of strontium ions were inhibited by dibutyryl cyclic AMP and by prostaglandin E 1. The results suggest that strontium ions induce platelet secretion largely via the liberation of arachidonate from membrane phospholipid with the subsequent biosynthesis of thromboxane A 2.
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