Abstract
New methods to improve the bone response to metallic implants are still emerging, ranging from surface modifications of the metal to coatings and drug delivery. One further development of coatings on implants is to incorporate bioactive ions in order to stimulate the bone response without the need of drug delivery. The aim of the current study is to prepare apatite coatings containing Sr and Si using a solution method, for the purpose of further optimising the bone response to metal implants. Titanium substrates were activated to induce the formation of coatings in modified PBS solutions. Soaking in PBS solutions with different concentrations of strontium and silicate at 37℃ or 60℃ produced coatings with different morphologies, thicknesses and compositions. Ion release experiments showed simultaneous release of Sr and Si from the coatings both in PBS and Tris-HCl. Analysis of the results using the Korsmeyer-Peppas model indicate that the release of ions from the coatings was a combination of Fickian diffusion and degradation of the coatings. This study shows that it is possible to coat Ti substrates with modified apatite with ion release functionality and thereby increase the possibilities for a tailored bone response in vivo.
Highlights
Hydroxyapatite (HA) is widely used as a coating to improve the bone-bonding of permanent implants for biomedical applications such as hip prostheses [1,2]
This study shows that it is possible to coat Ti substrates with modified apatite with ion release functionality and thereby increase the possibilities for a tailored bone response in vivo
Inductively coupled plasma-optical emission spectroscopy (ICP-OES) analysis indicated that the Sr content in the coating was lower than that of silicon which could explain why the coating in this study was similar to pure HA
Summary
Hydroxyapatite (HA) is widely used as a coating to improve the bone-bonding of permanent implants for biomedical applications such as hip prostheses [1,2]. By improving the bond between the implant and bone the risk of revision surgery can be reduced [3,4]. HA prepared with a mineralization method has been coloaded with bisphosphonates and antibiotics, with the purpose of promoting bone formation around the implant site and reducing the risk of infections [5]. Studies have shown that ion doped HA, i.e. hydroxyapatite containing foreign ions, is a promising way to improve the cell proliferation and in vivo bone tissue response without the addition of pharmaceutical agents [6,7,8]. Compared to pure HA, these modified HA have different solubility, crystallinity and topography, all of which are factors that are expected to influence the bone response around the implant [9]
Sign-in/Register to view highlights & summary Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
