Abstract
Probiotic bacteria, which are traditionally studied to aid intestinal functions, are also currently being researched for benefits in other parts of the body such as the oral cavity. In the case of throat infections caused by bacteria, which traditional treatment involves antibiotics, some researchers are studying the possibility of introducing special strains of commensal bacteria into the mouth that can specifically inhibit the tonsillitis agent Streptococcus pyogenes for both prevention and treatment of such disease. A PCR assay was used to identify Streptococcus salivarius subsp salivarius. Therefore, tests for the complete absence of toxicity of these strains are required to ensure their safe use in human trials. In this research, we evaluated the new Streptococcus salivarius subsp salivarius BIO5 strain for toxicity factors, as follows: clinical, ophthalmic lesions, behavioral observations, mortality, anatomopathological examination, biopsy, hematology, serum biochemistry, and urine analysis. This strain, isolated from the oral cavity and with bacteriocinogenic activity against S. pyogenes, showed a complete absence of toxicity and thus it may be used in replacement therapy as a probiotic.
Highlights
IntroductionNew strains of S. salivarius have been studied for the same purpose: control and treatment of tonsillitis as Probiotic bacteria, which are traditionally studied to aid intestinal functions, are currently being researched for benefits in other parts of the body such as the oral cavity
In the case of throat infections caused by bacteria, which traditional treatment involves antibiotics, some researchers are studying the possibility of introducing special strains of commensal bacteria into the mouth that can inhibit the tonsillitis agent Streptococcus pyogenes for both prevention and treatment of such disease
New strains of S. salivarius have been studied for the same purpose: control and treatment of tonsillitis as Probiotic bacteria, which are traditionally studied to aid intestinal functions, are currently being researched for benefits in other parts of the body such as the oral cavity
Summary
New strains of S. salivarius have been studied for the same purpose: control and treatment of tonsillitis as Probiotic bacteria, which are traditionally studied to aid intestinal functions, are currently being researched for benefits in other parts of the body such as the oral cavity. Commensal well as otitis and halitosis[9, 10]. Confirmatory tests for the complete absence of toxicity of the Streptococcus salivarius BIO5 strain are required. Microorganisms of the mouth, ears, and nose have been researched for the prevention or treatment of II. Material & Methods oropharyngeal diseases such as periodontitis, caries, We obtained one strain with clear evidence of sore throat, and otitis. The Streptococcus absence of toxicity of the Streptococcus salivarius subsp salivarius subsp salivarius BIO5 strain was tested by salivarius BIO5 strain[1].
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