Abstract
AbstractPregnant C57BL and DBA mice were treated with i. p. injection twice of 25% ethanol (3.97 g/kg × 2), four hours apart, on day 7, 8, 9, 10, 11, 12 or 13 of gestation. They were killed on day 18 of gestation, and the fetuses were examined for external and skeletal malformations. In order to determine the blood ethanol levels, nonpregnant animals were treated with the same dose of ethanol and then killed at 0.5‐16 hours after injection.Fetal mortalities of DBA mice were higher than those of C57BL mice. The body and brain growth retardations were severer and the incidence of malformations was higher in C57BL mice than in DBA mice. The most frequently observed malformations were microphthalmia and digital malformations in C57BL mice, and open eyelids in DBA mice. Blood ethanol reached the maximum level within half an hour after the second injection in both strains, and was significantly higher in DBA mice than in C57BL mice 2–15 hours after the second injection. It is difficult to explain the strain difference of embryotoxicity between C57BL and DBA mice on the basis of only the difference in blood ethanol level in the present study.
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