Abstract
ABSTRACT The objective of the present work was to develop stimuli-responsive PEGylated nanoparticles system comprising of xanthine oxidase, Bleomycin and diallyl trisulfide in order to promote their significance against cervical cancer HeLa cell line. In the synthesis of polyethylene glycol- xanthine oxidase, the modified polyethylene glycol was added to lysyl ϵ-amino group of xanthine oxidase to form amide linkage. Similarly, polyethylene glycol- xanthine oxidase-bleomycin sulphate and polyethylene glycol-diallyl trisulfide were synthesized with the molar ratio approach in order to form covalent interactions. The polyethylene glycol systems display synergistic cytotoxic action on HeLa cells, thus indicating a promising approach in the treatment of cervical cancer. In addition, polyethylene glycol- bleomycin sulphate-diallyl trisulfide proved to be a better anti-cancer agent in contrast to other prepared polyethylene glycol systems. It can be concluded disulfide interlinkages will play important role in near future for drug resistance cancer and for reducing cancer adverse events.
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