Abstract
The effects of bombesin, gastrin-releasing peptide, neuromedin C, ranatensin, and neuromedin B on hypothalamic arcuate neurons were tested in this study using extracellular single-unit recording in fresh brain tissue slices. Adult ovariectomized Sprague-Dawley rats were used for preparation of brain slices. All bombesin-like peptides in pmol ranges exhibited potent stimulatory effects on the firing of arcuate neurons i.e., gastrin-releasing peptide stimulated 90.9% ( n = 22), bombesin 78.0% ( n = 41), neuromedin C 63.2% ( n = 19), ranatensin 58.0% ( n = 22), and neuromedin B 50.0% ( n = 6) of arcuate neurons tested. Pretreatments with either [Leu 13-gy(CH 2NH)-Leu 14]-bombesin or [D-Phe 6, Des-Met 14]-bombesin 6−14 ethylamide, two bombesin antagonists, significantly blocked most of the actions of bombesin-like peptides tested. The present results further support the notion that bombesin-like peptides may play a significant role in the arcuate nucleus.
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