Abstract
After the chronic administration of phetharbital ( N-phenylbarbital) to man, a marked increase in the urinary excretion of 6 β-hydroxycortisol was observed. This increase in 6 β-hydroxycortisol excretion was not accompanied by a concomitant increase in the urinary excretion of 17-hydroxycorticosteroids (17-OHCS), suggesting that an increased adrenal output of cortisol is not responsible for the observed rise in 6 β-hydrocortisol excretion. The finding that phetharbital administration to guinea pigs increased the activity of an enzyme system in liver microsomes that hydroxylates cortisol in the 6 β-position does, however, offer an explanation for the observed increase in 6 β-hydroxycortisol excretion. The possible therapeutic uses of a nonhypnotic barbiturate such as phetharbital, which stimulates steroid metabolism, are discussed.
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