Abstract
The effect of LATS on protein synthesis in the mouse thyroid in vivo was compared to the action of TSH. A single injection of LATS or TSH in a thyroxine pretreated mouse failed to stimulate the incorporation of 3H-leucine into thyroidal protein. Injection of LATS for 5 days caused increased thyroid weight, augmented protein content, and increased incorporation of 3H-leucine. The specific activity of incorporated radioactivity per mg thyroid protein was significantly increased. Feeding a low iodine diet for 12 days increased incorporation of radioactivity and specific activity. Treatment with LATS or TSH for 8 days produced marked goiter formation accompanied by a high 131I thyroidal uptake. LATS stimulates protein synthesis in the thyroid, as does TSH. LATS does not appear to damage the thyroid cell since chronic exposure leads to marked goiter formation. (Endocrinology 85:344,1969)
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