Abstract
The main objective of our experiment was to prove the effect of mesenchymal stem cells of bone marrow (MSCs) on the stimulation of liver regeneration. The attention has been paid to adaptation of stem cells to the new environment and their transfer to anatomical structures. The experiment included 40 male Sprague Dawley (SD) rats aged 10 to 12 weeks. Biomodels were divided into five groups in the same number (n=8). Group 1 consisted of a control sample of eight healthy rats. Group 2 consisted of eight rats after liver resection without application of MSCs. Group 3 was after liver resection and application of MSCs. Group 4 after liver injury induce with Thioacetamide (TAA), without transplantation of MSCs. Group 5 was after chemical damage to the liver by TAA administration and MSCs transplantation. The process of stimulation of the liver was observed based on the laboratory values of alanine aminotransferase (ALT), albumin and bilirubin. The weight of the rats in each group was also compared. Animals were sacrificed after 1 day, 7 days, 14 days, and 21 days. In our experiment we found a statistically significant decrease in ALT (P≤0.001) and bilirubin (P≤0.001) was observed in the groups 3 and 5 (treated with MSCs) compared to the groups without MSCs (Groups 2 and 4). The increase in the albumin levels in the groups 3 and 5 was statistically significant. The results of our experiment led us to the conclusion, the transplantation of MSCs has important effect for the treatment and stimulation of liver regeneration following injury. MSCs administration may be extremely useful in a number of clinical applications in the treatment of liver tumors. It will allow us to perform extensive resection of the liver without risk of liver failure
Highlights
Recent research findings highlight the potential for the use of stem cells in the future [1]
The stimulation effect of mesenchymal stem cells (MSC) on the liver regeneration was observed based on the laboratory values of alanine aminotransferase (ALT), bilirubin, and albumin, control of the experimental animal weight, and histology
A statistically significant decrease in the ALT (p
Summary
Recent research findings highlight the potential for the use of stem cells in the future [1]. A change in the differentiation potential occurs when the stem cell leaves its original site and settles in the new tissue and under the influence of new signal molecules, it can change the destiny of the stem cell so much that it starts producing different cell lines [3; 4]. All these properties of MSCs, together with the enormous ability to differentiate into specialized cells – in our case hepatocytes – make them the most suitable candidates for cell therapy in the area of liver regeneration [5; 6]
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