Abstract
It is shown that zinc-metallothionein from rat liver increases 1.5-fold thein vitro incorporation of3H-thymidine in murine bone marrow cells. The same concentrations of zinc chloride and a mixture imitating zinc-metallothionein (zinc, cysteine, and albumin) inhibit DNA synthesis. In mice receiving an intraperitoneal injection of zinc-metallothionein 10–15 min before γ-irradiation, the incorporation of3H-thymidine and the content of nucleated cells in the bone marrow is 1.5- to 2-fold higher than those in unprotected animals, the number of endogenous splenic colonies in pretreated mice being 2.7-fold higher.
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