Abstract
Changes in plasma concentrations of corticosterone and β-endorphin (β-END) were determined in male rats after treatment with the selective 5-HT 1A agonist 8-hydroxy-2-(di-n-propylamino)tetralin (8-OH-DPAT) or the non-selective 5-HT agonist 6-chloro-2-(1-piperazinyl)pyrazine (MK-212). The administration of either 8-OH-DPAT or MK-212 increased plasma concentrations of both corticosterone and β-END in a dose-related manner. The corticosterone and β-END responses to 8-OH-DPAT were antagonized by spiperone and (−)-pindolol, both of which have been shown to have high affinity for the 5-HT 1A binding site. In contrast, antagonists which are selective for the 5-HT 2 receptor or non-selective 5-HT antagonists were without effect on the hormone responses to 8-OH-DPAT. The MK-212-induced increase in plasma concentrations of corticosterone and β-END were not affected by treatment with the 5-HT 1A antagonists spiperone and (−)-pindolol. However, the corticosterone and β-END responses to MK-212 were attenuated by the selective 5-HT 2 antagonists ketanserin, ritanserin and altanserin, as well as by the non-selective 5-HT antagonist metergoline. It is concluded that stimulation of either 5-HT 1A or 5-HT 2 receptors results in an activation of the hypothalamic-pituitary-adrenal axis in the rat.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
