Abstract
We examined the effects of nicotinic receptor agonists against beta amyloid (A β) cytotoxicity to rat cortical neurons. Administration of nicotine protected against A β-induced neuronal death. This neuroprotection was blocked by dihydro-beta-erythroidine, an α4 β2 nicotinic receptor antagonist. Furthermore, incubation with cytisine, a selective α4 β2 nicotinic receptor agonist, inhibited A β cytotoxicity. These results suggest that α4 β2 nicotinic receptor activation plays an important role in neuroprotection against A β cytotoxicity.
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