Abstract
The α-particle emitting radionuclides 223Ra (t 1 2 = 11.4 d), 224Ra (t 1 2 = 3.6 d), and 225Ac(t 1 2 = 10.0 d) may have a broad application in targeted radiotherapy provided that they could be linked to vehicles with tumor affinity. The potential usefulness of liposomes as carriers was studied in the present work. Radium and actinium radionuclides could be loaded in good yields into sterically stabilized lipsomes. Subsequent coating of the lipsomes with a folate-F(ab′) 2 construct yielded a product with affinity towards tumor cells expressing folate receptors. Radionuclide loaded liposomes showed excellent stability in serum in vitro.
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