Abstract
Revised structure of γ-lactone polyketide from Diaporthe sp. SXZ-19 and its C8-epimer were synthesized from TBS protected (S)-lactaldehyde and 2,3-O-cyclohexylidene- d -glyceraldehyde, which was derived from d -mannitol. The target γ-lactones were prepared via a common alkyne intermediate utilizing alkyne-aldehyde coupling reactions by changing the reaction conditions. In addition, Carreira and Ohira–Bestmann reactions were used as key steps to achieve the targets.
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