Abstract
In the past few years, it has become clear that individual stereoisomers--especially the enantiomers--of a biologically active chiral molecule may differ in potency, pharmacological action, metabolism, toxicity, plasma disposition, and urine excretion kinetics. This situation exists in all classes of therapeutically active agents including chiral anticancer agents. The chiral compounds used in standard and experimental cancer chemotherapy include leucovorin (LV), ifosfamide (IFF), buthionine sulfoximine (BSO), and verapamil (VER). Analytical methods for stereoselective separation of each of these compounds have been developed and applied to pharmacokinetic and pharmacodynamic studies. Pharmacological differences have been found between stereoisomers of all of these compounds and it is evident that the clinical effectiveness of these agents would be enhanced by the administration of only a single isomer.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
