Abstract
AbstractA diastereoselective Mannich reaction has been developed for the construction of stereogenic C−F units by the reaction of α‐fluoro‐substituted amides, including highly activated 3‐fluoro‐oxindoles, and simple linear fluoroacetamides with N‐tert‐butylsulfinylimines. This method provides a concise route to a variety of structurally diverse α‐fluoro‐β‐amino amides containing stereogenic fluorinated carbon centers. This protocol has the benefit of using readily accessible starting materials and is operationally simple. The Mannich reactions of cyclic and linear α‐fluoro‐substituted amides resulted in different stereochemical outcomes, suggesting that these substrates reacted via closed and open transition states, respectively.magnified image
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.