Abstract
The control of the stereochemistry at C-1 of cis-perhydroindane compounds, required for the synthesis of cardenolide analogs, has been achieved by epimerization of the dithiane derivative at C-5. Molecular modeling of this kind of compounds predicted the higher stability of the C-1-β-epimer in this and other derivatives, instead of the usually more stable C-1-α-epimer in the natural cardenolides and other calculated compounds.
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