Abstract
The antigenic specificity of bacterial capsular polysaccharides has been extensively investigated. The origin of this specificity arises from the diversity of the oligosaccharide epitopes of the polysaccharide. Nuclear magnetic resonance spectroscopy provides a very powerful tool for probing the structure of the oligosaccharide epitopes. Using this technique in conjunction with chemical methods, the structures of the serotype-specific capsular polysaccharide antigens of Rhodococcus equi have been investigated. These studies have led to the identification of several structural features which can be related to serologic type specificity. This review will focus on some stereochemical aspects of the antigen determinants. Nuclear magnetic resonance based methods for determination of bacterial polysaccharide primary structure and for stereochemical analysis of chiral acidic substituents are presented.
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