Abstract

The structural relation between physiologically active steroids and polycyclic aromatic hydrocarbons with carcinogenic properties is to include the relation cholesterol—steranthrene. Steranthrene in its angular form has very definite carcinogenic properties when tested by injection or application to the skin by painting. Experiments showed that the carcinogenic properties of steranthrene were equal to those of 3-methyl-cholanthrene and 3,4-benzpyrene. The present stand of knowledge concerning dehydrogenation and aromatisation of steroids in the mammalian organism is discussed.

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