Stężenie leptyny i omentyny-1 w surowicy eutroficznych, zdrowych noworodków donoszonych

Abstract

ObjectiveThe study of leptin and omentin-1 in adults and older children indicates on the relationship these hormones have with state of nutrition, diabetes, insulin-sensitivity and arterial hypertention. The effect of leptin and omentin on fetal growth in healthy neonates is not well known. AimThe evaluation of serum leptin and omentin concentrations in healthy, eutrophic full-term neonates according to their gender, anthropometric parameters and mode of mother's delivery. Materials and methodsThe study involved 79 (49 girls, 27 boys) neonates, among them 63 were vaginal born and 19 by cesarean section. Serum leptin and omentin-1 concentrations were measured between 3rd and 7th day of life by ELISA method. ResultsIt was found that mean serum leptin is significantly higher in girls than in boys and serum omentin-1 concentration significantly lower in female than in male neonates. Statistically significant (p<0.05) negative correlations between serum leptin level and body length, and between serum omentin-1 concentration and head circumference were observed. Mode of delivery had no influence on lepton and omentin-1 concentrations. Conclusions1) These data demonstrate that serum leptin and omentin-1 concentrations in healthy eutrophic full-term neonates are associated with their gender, leptin level with body length and omentin-1 with head circumference. 2) Birth weight and mode of mother's delivery do not have a significant influence on serum leptin and omentin-1 concentrations in full-term, eutrophic neonates.