Abstract
Abstract— The effects of selective inactivation of propionylcholinesterase (PrChE) by tetramonoisopropylpyrophosphortetramide (iso‐OMPA) on the steady state and regenerating levels of acetylcholinesterase (AChE) were investigated on the superior cervical ganglion (SCG) of the rat. Over the dosage range of 1.5‐40.0 μmol iso‐OMPA/kg intraperitoneally, which produced nearly total inactivation of ganglionic PrChE and 0‐35% inactivation of AChE, there was no subsequent increase in AChE activity above the control level. Single or repeated injections of iso‐OMPA at total doses of 5.0‐40.0 μmol/kg intraperitoneally caused no reduction in the rate of regeneration of ganglionic AChE during the 24 h following its inactivation by sarin, 2.0 μmol/kg intravenously. Both sets of findings differ from those obtained previously in a similar study of ganglionic AChE and butyrylcholinesterase (BuChE) in the cat. Possible reasons for this distinct species difference are discussed.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
