Abstract
Repaglinide (RPD) is a short-acting insulin secretagogue widely prescribed for the treatment of type 2 diabetes. In this study, RPD loaded ethyl cellulose/hydroxypropylmethylcellulose (EC/HPMC) floating microspheres (FM) have been formulated for gastric sustained release and improved bioavailability of RPD. Floating microspheres were prepared by oil in water emulsion solvent evaporation technique. A three levels Central-composite design (CCD) was applied to investigate the influence of different formulation components and process variables on the formulation responses and indicate the optimum using the numeric approach through the Minitab® software.
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