Abstract
Multivalent intrinsically disordered protein (IDP) complexes control many diverse cellular functions, such as tuning levels of transcription, coordination of cell-signaling events and regulating the assembly/disassembly of complex macromolecular architectures. These systems are difficult to characterize structurally, due to inherent conformational and compositional heterogeneity. Although electron microscopy (EM) is a powerful tool for visualizing multivalent complexes, the IDPs themselves are “invisible” by EM, which poses challenges to traditional methods of image analysis and structural interpretation.
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