Abstract
<p>Statins are the cornerstone for primary and secondary prevention of atherosclerosis. But statin monotherapy in some patients will not be sufficient to achieve an LDL-C target and increase the incidence of new-onset diabetes in a dose dependent manner, especially in women, elderly, presence of family history of type 2 diabetes and Asian ethnicity. Recently metformin, an old and effective antidiabetic medication, has been found to reduce LDL-C levels and has cardiac benefits for patients with T2D. Therefore, statins plus metformin may further reduce LDL-C levels and partly counteract statin-induced diabetes.</p>
Highlights
Statin monotherapy in some patients will not be sufficient to achieve an low density lipoprotein cholesterol (LDL-C) target and increase the incidence of new-onset diabetes in a dose dependent manner
It has been reported that statins increased the incidence of new-onset diabetes in a dose dependent manner especially in women, the elderly, or in the presence of a family history of type 2 diabetes (T2D) and Asian ethnicity.[1]
It was believed that the effect of metformin was associated with adenosine 5-monophosphateactivated protein kinase (AMPK), AMPK activated by metformin can suppress fatty acid desaturases (FADS) synthesis in liver 6
Summary
Statin monotherapy in some patients will not be sufficient to achieve an LDL-C target and increase the incidence of new-onset diabetes in a dose dependent manner. Statins plus metformin: a promising combination for prevention and treatment of atherosclerosis.
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