Abstract
Background: Little is known about the potential of statin-induced high-density lipoprotein cholesterol (HDL-C) increase to improve renal function in coronary heart disease (CHD) patients.
Highlights
Chronic kidney disease (CKD), including mild renal impairment, is recognized as an independent predictor of cardiovascular disease (CVD) in high-risk patients [1,2,3]
In our statin untreated patients, there was a gradual reduction in estimated glomerular filtration rate (eGFR) that became significant by the end of the 2nd year of the study; renal function continued to deteriorate until the end of the study
The present study addressed whether or not the statininduced high-density lipoprotein cholesterol (HDL-C) increase contributed to renal function improvement on top of low-density lipoprotein cholesterol (LDL-C) reduction and other secondary CVD prevention measures
Summary
Chronic kidney disease (CKD), including mild renal impairment, is recognized as an independent predictor of cardiovascular disease (CVD) in high-risk patients [1,2,3]. The Physicians’ Health Study reported that from 4,483 participating healthy men with a normal baseline renal function, those with low high-density lipoprotein cholesterol (HDL-C) and high non-HDL-C [low-density lipoprotein cholesterol (LDL-C) + very LDL-C (VLDL-C) + intermediate density lipoprotein cholesterol (IDL-C)] levels had double the risk for CKD after adjusting for other risk factors [5]. Non-HDL-C levels were associated with an increased risk for deterioration of renal function in patients with CKD [6]. Little is known about the potential of statin-induced high-density lipoprotein cholesterol (HDL-C) increase to improve renal function in coronary heart disease (CHD) patients
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