Abstract
Activation of hypothalamic agouti-related protein (AGRP)-expressing neurons is known to increase food intake in rodents. Here, Atasoy et al., using channel rhodopsin-assisted circuit mapping and pharmacogenetic techniques, showed that activation of inhibitory projections of AGRP neurons to a small population of oxytocin-expressing neurons in the paraventricular hypothalamus was sufficient to induce this effect. As this population of neurons is lost in Prader–Willi syndrome, these findings provide a mechanism for the insatiable hunger associated with this syndrome and perhaps for other eating disorders.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
