Abstract
Encapsulating chemotherapeutic agents in liposomes improves targeting and efficacy of treatments against some tumors. The present work aims at evaluating if sonosensitive liposomes combined with cavitation for drug delivery enhance efficacy and reduce toxicity. Two focused beams were combined for stabilizing the cavitation cloud and an imaging probe used for guidance. Each 1MHz focused transducer had a 5cm diameter and focal length. Exposure conditions were 10.8kW/cm2 Isppa, 250Hz PRF and 1% duty cycle. Phosphatidylcholine-based nongaseous liposomes were loaded with Doxorubicin. To control for mechanical tissue damage, AT2 Dunning tumors on rats were first exposed to ultrasound only. Treatment induced temperature rose below 0.5° C. The tumor growth was not significantly slowed down by ultrasound, but histological examination of tumors evidenced large areas of necrosis which resorbed one week after ultrasound. The new liposomes were compared with conventional HSPC-based liposomes in terms of efficacy and t...
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