Abstract
The drying process of Uncariae Ramulus Cum Uncis (URCU), a kind of traditional Chinese medicine, was studied in a scale dryer in laboratory at 65°C. It was observed that the alkaloids content of URCU firstly showed a tendency of increasing and then decreasing after reaching the peak at the 570th minute in the process of constant temperature drying. Moreover, the coagulation time of rabbit determined by test tubes has been adopted to study the effect imposed by the content of alkaloids on the anticoagulating activity of URCU. In addition, the software of Minitab was also utilized to fit the correlation between the content of alkaloids and the anticoagulating activity of URCU. The results obtained demonstrated that anticoagulant activities were available in both rhynchophylline and isorhynchophylline, among which the latter was the stronger one, while procoagulant activity was shown in corynoxeine. The case study can provide a useful reference for the research on drying other Chinese herbal medicines (CHMs) and further study on URCU.
Highlights
It is known worldwide and acknowledged that Chinese herbal medicines (CHMs) have been employed in the therapy of many diseases for several thousands of years in both China and neighbor countries and they play an increasingly important role in modern pharmaceutical industry [1]
4.2. e Measurement Results Obtained from the Sample Solution in Different Drying Conditions. e peak areas shown in the high-performance liquid chromatography (HPLC) spectrum of water extracts from 13 samples prepared in Section 3.1.4 were obtained
Previous studies on the most suitable model of Uncariae Ramulus Cum Uncis (URCU) and its related parameters are available, the variation existing in the content of three alkaloids in URCU and their bioactivity during the drying process is still not clear
Summary
It is known worldwide and acknowledged that Chinese herbal medicines (CHMs) have been employed in the therapy of many diseases for several thousands of years in both China and neighbor countries and they play an increasingly important role in modern pharmaceutical industry [1]. Due to their great bioactivity and low toxicity, they have attracted much attention from western countries [2]. The appearance of spectrum-effect relationship provides a method to identify the main active compounds of CHM, which is of vital importance in development of CHM
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