Abstract
Full-genome sequencing showed that a recently emerged and hypervirulent clone of group A Streptococcus type emm59 active in Canada and parts of the United States has now caused severe invasive infections in rural northeastern Wyoming. Phylogenetic analysis of genome data indicated that the strain was likely introduced from Montana.
Highlights
Full-genome sequencing showed that a recently emerged and hypervirulent clone of group A Streptococcus type emm59 active in Canada and parts of the United States has caused severe invasive infections in rural northeastern Wyoming
Four of the authors (M.L.M., P.L.F., R.N., and M.M.) cared for 4 patients whose cases were temporally clustered and who had severe invasive infections caused by group A Streptococcus (GAS) in northeastern Wyoming, USA
One of the authors (J.M.M.) suggested that the recent and remarkable change in the epidemiologic and virulence behavior of emm59 GAS strains in Canada and the United States warranted increased attention by public health authorities and infectious diseases practioners [2]
Summary
Full-genome sequencing showed that a recently emerged and hypervirulent clone of group A Streptococcus type emm active in Canada and parts of the United States has caused severe invasive infections in rural northeastern Wyoming. A striking increase in the frequency and severity of invasive infections caused by type emm strains recently occurred in Canada [1]. Four of the authors (M.L.M., P.L.F., R.N., and M.M.) cared for 4 patients whose cases were temporally clustered and who had severe invasive infections caused by GAS in northeastern Wyoming, USA. Case-patient 3 was a physician who had cared for case-patients 1 and 2 These infections occurred in an area close to where a cluster of 6 invasive emm infections occurred in Montana in 2010 [2].
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